IKZF1 anticorps (PE)

N° du produit ABIN2662755

Cet anticorps Souris Monoclonal détecte spécifiquement IKZF1 dans FACS. Il présente une réactivité envers Souris.

Aperçu rapide pour IKZF1 anticorps (PE) (ABIN2662755)

Antigène: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IKZF1 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: 2A9-Ikaros

Détail du produit anti-IKZF1 anticorps (PE)

Aucune reactivité croisée: Souris

Purification: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotype: IgG1 kappa, IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur IKZF1

Antigène: IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Autre désignation: Ikaros

Sujet: Ikaros family members, including Ikaros and Helios, play a role in the development of lymphocytes and B and T cells. They are nuclear factors that colocalize with DNA replication machinery components in higher-order chromatin structures and respond to signaling events, such as T cell activation. Helios and Ikaros bind to similar DNA sequences, and they function as hemopoietic-specific transcription factors. Members of the Ikaros family contain zinc-finger domains that are involved in DNA-binding and in the formation of homodimers and heterodimers between Ikaros family members. Expression of Ikaros is primarily detected in the thymus and spleen, where it is essential for regulating T cell specific gene transcription and for the differentiation and commitment of early hemopoietic progenitors to the B and T lymphoid lineages. Ikaros and Helios also appear to regulate cell cycle entry by inducing transcriptional repression under varying conditions and, thereby, mediate T cell activation and IL-2 mediated signaling events.

Pathways: Production of Molecular Mediator of Immune Response